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4,4'-(1,3-Phenylene-bis(1-methylethylidene))bis-phenol

CAS 13595-25-0
35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A bisphenol derivative structurally related to BPA, classified as a skin sensitiser and suspected reproductive toxicant, raising endocrine disruption concerns that have led to increasing EU regulatory restrictions on bisphenol-class compounds.

This bisphenol compound (CAS 13635-25-0) is structurally analogous to bisphenol A. It carries GHS hazard classifications H317 (skin sensitiser), H361f (suspected reproductive toxicant), and H411 (aquatic chronic toxic) under EU Regulation 1272/2008. Bisphenol derivatives are under increasing regulatory scrutiny in the EU under REACH and the Cosmetics Regulation due to endocrine-disrupting concerns, with BPA already banned in cosmetic products in the EU via a 2016 SCCS opinion.

Known concerns

  • Skin sensitiser (H317)
  • Suspected reproductive toxicant (H361f)
  • Endocrine-disrupting chemical of concern
  • Environmental toxicity (H411)
  • Structural similarity to bisphenol A raises regulatory concern

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.