4,4'-(1,3-Phenylene-bis(1-methylethylidene))bis-phenol
Caution
CAS Number: 13595-25-0
About 4,4'-(1,3-Phenylene-bis(1-methylethylidene))bis-phenol
A bisphenol derivative structurally related to BPA, classified as a skin sensitiser and suspected reproductive toxicant, raising endocrine disruption concerns that have led to increasing EU regulatory restrictions on bisphenol-class compounds.
Detailed Analysis
This bisphenol compound (CAS 13635-25-0) is structurally analogous to bisphenol A. It carries GHS hazard classifications H317 (skin sensitiser), H361f (suspected reproductive toxicant), and H411 (aquatic chronic toxic) under EU Regulation 1272/2008. Bisphenol derivatives are under increasing regulatory scrutiny in the EU under REACH and the Cosmetics Regulation due to endocrine-disrupting concerns, with BPA already banned in cosmetic products in the EU via a 2016 SCCS opinion.
Known Concerns
- ⚠ Skin sensitiser (H317)
- ⚠ Suspected reproductive toxicant (H361f)
- ⚠ Endocrine-disrupting chemical of concern
- ⚠ Environmental toxicity (H411)
- ⚠ Structural similarity to bisphenol A raises regulatory concern
Safety Score
Caution
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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