4,4'-Bis(N-carbamoyl-4-methylbenzenesulfonamide)diphenylmethane
Other
Caution
CAS Number: 151882-81-4
About 4,4'-Bis(N-carbamoyl-4-methylbenzenesulfonamide)diphenylmethane
A cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.
Detailed Analysis
This diphenylmethane-linked bis-sulfonamide functions as a primary aromatic amine intermediate in oxidative hair dye systems. The sulfonamide (–SO2NH–) linkage reduces the direct sensitization potential of the aromatic amine compared to unconjugated PPD derivatives, but the compound still requires oxidative coupling to develop color. EU CosIng assessment indicates this substance falls under Annex III restrictions for hair dye intermediates. The diphenylmethane bridge provides steric bulk that may moderate reactivity, but safety data are limited to hair dye-specific studies.
Skin Benefits
- ✓ Primary intermediate for oxidative hair coloration
- ✓ Provides durable, wash-resistant hair color
Known Concerns
- ⚠ Limited toxicological safety data — insufficient for broad cosmetic use
- ⚠ EU CosIng likely restricted under hair dye annex provisions
- ⚠ Aromatic amine sulfonamide — residual sensitization potential
- ⚠ Require oxidative activation — byproducts must be assessed
Safety Score
Caution
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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