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4,4'-DIAMINODIPHENYLAMINE

CAS 537-65-5
22

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

4,4'-diaminodiphenylamine is a cosmetic ingredient. Exercise caution due to limited available safety data.

4,4'-Diaminodiphenylamine (CAS 537-65-5) is listed in EU Regulation 1223/2009 Annex II/1309, meaning its use in cosmetic products is prohibited. Annex II contains substances banned from cosmetic products due to safety concerns. This aromatic amine has structural alerts for sensitisation and genotoxicity. The restriction reference II/1309 places it in the category of hair dye intermediates prohibited for cosmetic use. Not permitted in any EU cosmetic product category regardless of concentration.

Known concerns

  • Listed in EU Annex II (prohibited substances)
  • Prohibited for cosmetic use in the EU
  • Structural alerts for skin sensitisation
  • Potential genotoxicity concern

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.