4,4'-DIAMINODIPHENYLAMINE

22

Avoid

CAS Number: 537-65-5

About 4,4'-DIAMINODIPHENYLAMINE

4,4'-diaminodiphenylamine is a cosmetic ingredient. Exercise caution due to limited available safety data.

Detailed Analysis

4,4'-Diaminodiphenylamine (CAS 537-65-5) is listed in EU Regulation 1223/2009 Annex II/1309, meaning its use in cosmetic products is prohibited. Annex II contains substances banned from cosmetic products due to safety concerns. This aromatic amine has structural alerts for sensitisation and genotoxicity. The restriction reference II/1309 places it in the category of hair dye intermediates prohibited for cosmetic use. Not permitted in any EU cosmetic product category regardless of concentration.

Known Concerns

  • ⚠ Listed in EU Annex II (prohibited substances)
  • ⚠ Prohibited for cosmetic use in the EU
  • ⚠ Structural alerts for skin sensitisation
  • ⚠ Potential genotoxicity concern

Safety Score

22

Avoid

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.