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4,4'-Methylenedi-o-toluidine

CAS 838-88-0
20

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Methylenedi-o-toluidine is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

4,4'-Methylenedi-o-toluidine (MDI-ortho-toluidine) is classified as a suspected carcinogen (H350) and shows acute aquatic toxicity (H400, H410, H411). It is not listed in EU Annex II or III but falls under general CMR substance regulation requiring authorization under EU REACH. Its structural similarity to known carcinogenic aromatic amines (including o-toluidine itself) raises significant safety concerns for any cosmetic application.

Known concerns

  • H350 suspected carcinogen
  • H400/H410/H411 aquatic toxicity
  • CMR classification concern
  • Related to known carcinogenic aromatic amines

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.