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4,4'-Methylenedianiline

CAS 101-77-9
2

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

4,4'-methylenedianiline is a cosmetic ingredient. Exercise caution due to limited available safety data.

4,4'-Methylenedianiline is listed in Annex II of EU Regulation (EC) No 1223/2009 and is classified as a Category 1B carcinogen under CLP Regulation (EC) No 1272/2008. It was formerly used in polyurethane polymer synthesis and epoxy resin systems. MDA is readily absorbed through skin and is hepatotoxic. It also functions as a strong contact allergen, making it particularly dangerous in topical products.

Known concerns

  • Prohibited in EU cosmetics (Annex II)
  • Category 1B carcinogen (CLP)
  • Confirmed skin sensitizer
  • Hepatotoxic
  • Readily absorbed through skin

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.