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Aromatic amine (CMR, banned)

4,4'-Thiodianiline and its salts

CAS 139-65-1
4

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

An industrial aromatic amine once used in dye manufacture, now banned from EU cosmetics as a probable carcinogen. It has no skincare function and is on the regulation's prohibited substances list.

Skin benefits

  • No cosmetic benefit; used historically as a dye intermediate in industrial chemistry
  • Appears in regulation only so the prohibition is unambiguous

Known concerns

  • Listed in EU Cosmetics Regulation Annex II as prohibited (CMR substance)
  • Classified by IARC as possibly carcinogenic to humans (Group 2B) and as Carc. 1B under EU CLP
  • Aromatic amine with mutagenicity concerns
  • Skin contact can trigger sensitisation and systemic absorption

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.