4-Aminophenol

42

Caution

CAS Number: 123-30-8

About 4-Aminophenol

A coal tar derivative used as an oxidative hair dye intermediate with skin sensitization concerns and EU restrictions under Annex III.

Detailed Analysis

4-Aminophenol (para-aminophenol, p-AP) is an aromatic amine widely used as a coupling agent in oxidative (permanent) hair dye systems. It is listed in EU Regulation 1223/2009 Annex III, part 1, with restrictions on maximum concentration and conditions of use. Like other p-phenylenediamine derivatives, it can cause severe allergic contact dermatitis in sensitized individuals. Its hazard profile includes potential for skin sensitization and methemoglobinemia from systemic absorption.

Skin Benefits

  • ✓ Used as hair dye intermediate for dark shades

Known Concerns

  • ⚠ EU Annex III restricted as oxidative hair dye component
  • ⚠ Known skin sensitizer - can cause severe allergic contact dermatitis
  • ⚠ Restricted to oxidative hair dye use only
  • ⚠ Must not be used for eyebrows and eyelashes

Safety Score

42

Caution

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.