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Skin Conditioning

4-Hydroxyphenyl-alpha-D-glucopyranoside

CAS 84380-01-8 Updated
78

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Alpha-arbutin — the more stable, more potent arbutin isomer. Blocks the pigment-making enzyme tyrosinase to fade dark spots. SCCS-reviewed and safe up to 2% in face creams.

Skin benefits

  • Inhibits tyrosinase to reduce dark spots
  • More stable than beta-arbutin
  • Gentler than hydroquinone
  • Brightening for melasma/PIH

Known concerns

  • Slow in-vivo hydrolysis releases trace hydroquinone
  • SCCS recommends max 2% in face creams
  • Avoid combining with strong oxidizers

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.