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Approved preservative

4-Isopropyl-m-cresol

CAS 3228-02-2
65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

4-Isopropyl-m-cresol, also called o-Cymen-5-ol or biosol, is an EU-approved cosmetic preservative effective against bacteria and fungi. It is permitted at restricted concentrations with good tolerability in typical use.

Skin benefits

  • Effective antimicrobial preservative also known as o-Cymen-5-ol
  • Permitted in EU cosmetics under Annex V as preservative
  • Active against bacteria and fungi at low concentration
  • Used in oral care and skincare preservation

Known concerns

  • Phenolic compound with low irritation potential in sensitive users
  • Concentration-restricted in EU finished cosmetics
  • Some sensitization cases reported
  • Not for use on broken or compromised skin

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.