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4-Methyl-m-phenylene diisocyanate (Toluene 2,4-diisocyanate)

CAS 584-84-9
20

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Toluene 2,4-diisocyanate is a severe respiratory sensitizer (H334, H330) and is classified as a suspected carcinogen (H351) and mutagen (H341). It is listed on EU Annex II (Regulation (EC) No 1223/2009) as a banned substance for cosmetic products due to its extreme sensitizing potential.

Known concerns

  • Respiratory sensitizer (H334)
  • Suspected carcinogen (H351)
  • Suspected mutagen (H341)
  • Serious eye and skin irritation (H318, H315)
  • Banned under EU Annex II

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Related others

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.