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4-Methylaminophenol and its salts

CAS 150-75-4 - 55-55-0 - 1936-57-8
32

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A phenolic hair dye intermediate with skin sensitization and methemoglobinemia concerns, not formally restricted in EU Annexes but raising significant safety concerns.

4-Methylaminophenol (para-methylaminophenol) and its salts are aromatic amine derivatives used as oxidative hair dye intermediates. Like other p-aminophenol derivatives, they can cause severe allergic contact dermatitis in sensitized individuals and have been associated with methemoglobinemia upon systemic absorption. While not explicitly listed in EU Regulation 1223/2009 Annex II or III with restrictions, its structural relationship to restricted hair dye intermediates and its toxicity profile raise concerns about its current cosmetic authorization.

Skin benefits

  • Used as hair dye intermediate for oxidative coloration

Known concerns

  • Known skin sensitizer - strong allergic contact dermatitis risk
  • Potential methemoglobinemia concern
  • Structural alert for genotoxicity
  • Not formally restricted but safety questioned

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.