4-tert-Butylphenol
Safety score · 0–100
Caution
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
An alkylphenol with endocrine-disrupting potential and skin sensitization concerns, subject to EU regulatory review as a substance of very high concern.
4-tert-Butylphenol is a branched alkylphenol used as an intermediate in chemical synthesis and occasionally in cosmetic formulations. Alkylphenols, including 4-tert-butylphenol, have been identified as potential endocrine-disrupting chemicals (EDCs) in aquatic toxicity studies. The SCCS has expressed concern about alkylphenol use in cosmetic products due to potential estrogenic activity. It is not explicitly banned but is under regulatory scrutiny in the EU.
Skin benefits
- Used as fragrance fixative
- Provides antioxidant stabilization in some formulations
Known concerns
- Potential endocrine-disrupting chemical (EDC)
- Aquatic toxicity concern - classified as hazardous to aquatic environment
- Skin sensitizer
- Under EU regulatory review as potential SVHC
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.