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4-Vinylcyclohexene

CAS 100-40-3
38

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

4-Vinylcyclohexene is a cosmetic ingredient used in product formulation. Exercise caution due to limited available safety data.

4-Vinylcyclohexene is an unsaturated cyclic hydrocarbon that can form epoxide metabolites (4-vinylcyclohexene diepoxide) in vivo, raising significant toxicological concern. The parent compound is classified by IARC as possibly carcinogenic to humans (Group 2B). It is not listed in EU Regulation 1223/2009 Annexes as an authorized ingredient, suggesting it lacks the safety data required for cosmetic use. The structural alerts for carcinogenicity via epoxide formation are particularly concerning for a cosmetic ingredient.

Known concerns

  • IARC Group 2B possible carcinogen
  • Metabolizes to carcinogenic epoxide (4-vinylcyclohexene diepoxide)
  • Not authorized for cosmetic use in EU
  • Skin sensitization and irritation concerns

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.