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5,5'-Di-isopropyl-2,2'-dimethylbiphenyl-4,4'-diyl dihypoiodite (thymol iodide)

CAS 552-22-7
48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

An iodine-carrier antiseptic compound that releases thymol and iodine on skin contact, facing moderate regulatory restrictions due to sensitization potential and iodine exposure concerns.

Thymol iodide (also known as thymol iodide or bithionol-free iodinated thymol) is an iodinated biphenyl compound that releases iodine and thymol upon contact with skin, providing antiseptic activity. It is listed in EU Annex III of Cosmetics Regulation 1223/2009 with specific restrictions on maximum concentration. Iodine-releasing compounds face regulatory scrutiny due to potential thyroid effects and contact dermatitis risk with repeated exposure.

Skin benefits

  • Antiseptic/disinfectant properties
  • Broad-spectrum antimicrobial activity from iodine release

Known concerns

  • Iodine release may affect thyroid function with extensive use
  • Skin sensitization potential
  • EU Annex III restricted compound
  • Potential for photoallergic reactions

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.