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5-CYCLOHEXADECENONE

CAS 37609-25-9
72

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

5-CYCLOHEXADECENONE is a cosmetic ingredient used in product formulation. Exercise caution due to limited available safety data.

5-Cyclohexadecenone is a macrocyclic enone structurally related to civetone, used as a fragrance ingredient providing warm, musky, and slightly animalic scent notes. It is not subject to restriction under EU Regulation 1223/2009 and has a clean safety profile in skin sensitisation testing at typical use levels. Its macrocyclic structure contributes to excellent substantivity on skin.

Skin benefits

  • Provides warm, animalic musks fixative properties
  • Enhances fragrance substantivity on skin

Known concerns

  • Low concern at standard cosmetic fragrance use levels
  • May require allergen declaration depending on source and IFRA classification

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.