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Fragrance

6-METHYLQUINOLINE

CAS 91-62-3
46

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A methylated quinoline — the quinoline family carries genotoxicity and rodent carcinogenicity signals. Orange on structural-class caution.

6-Methylquinoline (CAS 91-62-3) is a methyl-substituted quinoline used in perfumery for leathery, earthy, tobacco notes. The parent quinoline has been evaluated by IARC and NTP with evidence of hepatocarcinogenicity in rodents and positive genotoxicity in multiple assays. Methylation does not remove the underlying ring system reactivity relevant to those findings. GHS classifications include acute oral toxicity and skin/eye irritation. Public CIR/SCCS monographs are limited. Under RIFM/IFRA, quinoline-type materials are managed at low use percentages; conservative cosmetic assessment places the material in the orange tier rather than a default-yellow.

Function

PERFUMING

Skin benefits

  • Leather/tobacco fragrance note

Known concerns

  • Quinoline class — carcinogenicity signal in parent
  • Genotoxicity signal
  • Acute toxicity
  • Limited cosmetic data

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.