8-CYCLOHEXADECENONE

Fragrance

58

Moderate

CAS Number: 3100-36-5

About 8-CYCLOHEXADECENONE

A macrocyclic musk ketone — gives a clean, musky scent. Main concern is its high toxicity to aquatic life. May also irritate skin.

Detailed Analysis

8-Cyclohexadecenone (C₁₆H₂₈O, MW 236.39, CID 534634) is a macrocyclic ketone musk fragrance. GHS classifications include H400 (very toxic to aquatic life, 100%), H410 (very toxic to aquatic life with long-lasting effects, 100%), and H315 (skin irritation, 47.2%). PubChem safety score of 50. While macrocyclic musks are generally safer than polycyclic or nitro musks for human health, this particular compound shows significant aquatic ecotoxicity and some skin irritation potential.

What It Does

PERFUMING

Known Concerns

  • ⚠ Very toxic to aquatic life (H400, 100%)
  • ⚠ Very toxic to aquatic life with long-lasting effects (H410, 100%)
  • ⚠ Causes skin irritation (H315, 47.2%)
  • ⚠ Environmental persistence

Safety Score

58

Moderate

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

🏛

EU CosIng Database

European Commission cosmetic ingredient registry

Check your products for 8-CYCLOHEXADECENONE

Scan any cosmetic product to see if it contains this ingredient and get a full safety breakdown.

Download LuxSense

This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.