Skin Conditioning
ACETYL HEXAPEPTIDE-37
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A synthetic six-amino-acid peptide marketed as a skin-smoothing signal peptide. Widely tolerated at trace use levels, but efficacy rests largely on supplier data.
Acetyl hexapeptide-37 is a short synthetic peptide capped with an acetyl group to improve stability and skin affinity. It is sold as a marker-style peptide intended to modulate skin surface appearance and is typically used at 0.5–5% of a carrier solution (active peptide in the ppm range). Short peptides as a class show very low irritation and sensitization potential, and no specific GHS hazards are associated with this INCI. However, no CIR or SCCS monograph covers this peptide, and independent peer-reviewed efficacy data is sparse — most claims trace back to supplier white papers. Purity and residual-solvent profile depend on the manufacturer.
Function
Skin benefits
- Marketed as a smoothing signal peptide
- Used at trace concentrations
- Low sensitization profile typical of short peptides
Known concerns
- Efficacy claims rely on supplier data
- No CIR/SCCS review
- Purity varies between manufacturers
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.