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Skin Conditioning

(SH-OLIGOPEPTIDE-78 PENTA-(S-SILKWORM HEXAPEPTIDE-1)) PEPTIDES

68

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A penta-substituted version of the SH-Oligopeptide-78/silkworm hybrid above. Same novel class; limited public review.

This INCI is the penta-substituted version of the previous ingredient — SH-Oligopeptide-78 conjugated with five copies of the silkworm-derived hexapeptide-1 sequence. As with the di-substituted form, the class sits at the edge of cosmetic regulation because growth-factor-analog peptides blur the line with pharmaceuticals. No CIR or SCCS review. Used at trace levels in anti-aging formulations. Default cautious scoring applies.

Skin benefits

  • Bioengineered peptide with 5-fold silkworm hexapeptide decoration
  • Cosmetic positioning for anti-aging
  • Very low use concentration limits exposure

Known concerns

  • Growth-factor-analog peptides — regulatory caution
  • No CIR or SCCS review
  • Efficacy data supplier-driven
  • Bioengineered protein concerns

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Related skin conditionings

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.