Conditioning Agent
SH-POLYPEPTIDE-18
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A recombinant human Interleukin-1 Beta analogue produced in E. coli that functions as a skin conditioning agent, with good tolerability in topical cosmetics at low concentrations.
sh-Polypeptide-18 is a recombinant human single-chain peptide produced by fermentation in E. coli, identical to a portion of human Interleukin-1 Beta. IL-1 Beta is a well-characterised cytokine with anti-inflammatory activity that has been used in topical cosmetic formulations. It is not restricted under EU cosmetics regulation, though its immunological activity means it should be used at appropriately low concentrations in leave-on products.
Function
Skin benefits
- Anti-inflammatory skin conditioning
- May support skin barrier homeostasis
- Anti-aging potential through cytokine-mediated pathways
Known concerns
- Immunological activity requires concentration control
- Bacterial expression system requires purity assessment
- Not suitable for use on compromised skin
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.