Conditioning Agent
RH-POLYPEPTIDE-6
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A recombinant human Interleukin-10 produced in E. coli with anti-inflammatory properties but subject to EU restriction under Annex II/416 due to its immunological activity.
rh-Polypeptide-6 is a recombinant human single-chain peptide of 178 amino acids, identical to human Interleukin-10, produced by fermentation in E. coli. IL-10 is a potent anti-inflammatory cytokine. It carries EU CosIng restriction II/416, which relates to its classification as a substance requiring careful evaluation. The restriction is consistent with SCCS guidance on bioactive peptides in cosmetics, though topical use at low concentrations is generally considered acceptable.
Function
Skin benefits
- Potent anti-inflammatory activity
- Skin protecting function
- May reduce signs of irritation and redness
Known concerns
- EU CosIng restriction II/416 indicates regulatory concern
- Immunological activity requires careful concentration control
- Bacterial expression system demands thorough purity assessment
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related conditioning agents
Check your shelf
Find RH-POLYPEPTIDE-6 in your products.
Scan any cosmetic product with LuxSense to see if it contains RH-POLYPEPTIDE-6 and get a full ingredient breakdown with safety scores.
This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.