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Skin Conditioning

NICOTINOYL OCTAPEPTIDE-13

70

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

An eight-amino-acid peptide with a niacin cap, used at ppm levels for skin-conditioning and brightening. Well-tolerated; evidence base is supplier-led.

Nicotinoyl octapeptide-13 is a synthetic octapeptide functionalized with a nicotinoyl (vitamin B3) group. It combines peptide signaling with niacinamide-style benefits including brightening and barrier support. Used in leave-on skincare at very low parts-per-million levels. Nicotinic acid derivatives can cause transient flushing in some users. No SCCS or CIR review is available for this specific ingredient; efficacy data is generated by the supplier. No GHS hazards apply at cosmetic-grade use levels.

Function

ANTIOXIDANT, SKIN PROTECTING

Skin benefits

  • Niacin-conjugated peptide for skin conditioning
  • Used at trace concentrations
  • Plausible brightening and barrier support

Known concerns

  • No independent regulatory dossier
  • Potential transient flushing from nicotinoyl moiety
  • Efficacy claims supplier-driven

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.