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Modified synthetic peptide

ACETYL ISOLEUCYL D-OLIGOPEPTIDE-1 AMIDE

55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Acetylated D-amino acid oligopeptide amide developed for stability. No dedicated regulatory review; class data on capped cosmetic peptides indicates generally low acute irritation.

Function

ANTIMICROBIALANTI-SEBUMPRESERVATIVESKIN CONDITIONING - MISCELLANEOUS

Skin benefits

  • Acetyl and D-amino acid modifications increase peptide stability against skin proteases
  • Amide capping reduces degradation versus free acid peptides
  • Defined synthetic active with low batch variability

Known concerns

  • No public CIR or SCCS opinion identified for this specific D-oligopeptide-1 amide derivative
  • Novel chemistry lacks long-term human safety data
  • D-amino acid peptides have less metabolic clearance data than L-analogs

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.