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Synthetic peptide (cocktail)

ACETYL OCTAPEPTIDE-3 OLIGOPEPTIDE-133

78

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A blend of synthetic peptides marketed as a botox-alternative for fine lines. Generally well tolerated topically, but real-world efficacy at cosmetic strengths is modest at best.

Skin benefits

  • Synthetic peptide marketed for expression-line smoothing effects
  • Targets SNARE-related signalling to reduce muscle contraction in skin
  • Generally low irritation in formulated products
  • Lab-made, so reproducible and free of botanical allergens

Known concerns

  • Topical penetration to active sites is debated in dermatology literature
  • Limited independent clinical evidence at consumer-typical concentrations
  • Cost and marketing claims often outpace published data
  • Long-term skin safety database is short

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Same plant / compound family

78
ACETYL OCTAPEPTIDE-3
Skin Conditioning

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.