Skin Conditioning
ACETYL S-INDIAN COBRA OLIGOPEPTIDE-1
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A synthetic peptide inspired by a fragment of Indian cobra venom, marketed for "Botox-like" anti-wrinkle effects. Novel and bioactive — caution is warranted.
This is a synthetic, N-acetylated oligopeptide modeled on a sequence found in Indian cobra (Naja naja) venom. Snake-venom peptides include bioactives with potent neuromuscular and cardiovascular effects; cosmetic mimetics aim to weakly modulate acetylcholine release at the neuromuscular junction, producing a purported "expression line relaxation" effect. The "S-" prefix indicates synthetic, not extracted. Efficacy evidence is modest and mostly supplier-driven; no CIR or SCCS review exists. The class is inherently pharmacological-adjacent, and some cosmetic jurisdictions view venom-mimetic peptides with regulatory caution. Use concentrations are typically very low (0.0001-0.001%). Avoid near broken skin and during pregnancy by default conservatism.
Skin benefits
- Synthetic peptide mimicking a snake-venom-derived bioactive sequence
- Marketed for Botox-like neuromuscular relaxation claims
- Very low cosmetic use concentrations
Known concerns
- Designed to mimic a venom peptide — inherent bioactive class concern
- No CIR or SCCS review
- Efficacy claims rely on low-quality studies
- Long-term use data lacking
- Pharmacological mimicry may trigger regulatory scrutiny
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.