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Fragrance

ALPHA-ETHOXYPHENETOLE

CAS 5426-78-8
65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

An ethoxylated phenyl ether used as a specialty fragrance material. Thin public data — defaulted to a conservative yellow.

Alpha-ethoxyphenetole (CAS 5426-78-8) is a specialty fragrance material with an ether/acetal architecture. Publicly available SCCS/CIR cosmetic safety monographs are limited. Acetal-type structures can hydrolyze under acidic conditions to regenerate the corresponding aldehyde, which is a relevant formulation consideration. No established sensitization or carcinogenicity concerns have been flagged for this specific structure, but the absence of data is itself the primary reason for a conservative rating. RIFM/IFRA presumably manage its use; no leave-on safety case can be made from public literature alone.

Function

PERFUMING

Skin benefits

  • Specialty fragrance character

Known concerns

  • Limited public toxicology
  • Potential acetal hydrolysis under acidic conditions

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.