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AMENTOFLAVONE

CAS 1617-53-4
80

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A naturally occurring biflavonoid antioxidant found in Ginkgo biloba and other plants, with anti-inflammatory and antioxidant properties used in anti-aging cosmetics.

Amentoflavone is a bis-flavonoid (a dimer of apigenin or luteolin) found in medicinal plants including Ginkgo biloba and Hypericum perforatum. It is not listed in EU CosIng Annexes with restrictions, indicating permitted cosmetic use. It acts as an antioxidant and anti-inflammatory through NF-κB and MAPK pathway inhibition. Available data show no significant toxicity, though it has been studied for potential hormonal activity at high doses. Used in anti-aging and calming skincare formulations at low concentrations.

Skin benefits

  • Potent antioxidant activity
  • Anti-inflammatory
  • Anti-aging via collagenase inhibition
  • Calming and soothing

Known concerns

  • No EU restrictions — but not formally evaluated in CosIng
  • Mild hormonal activity noted in some in vitro studies at high doses

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.