Anti-glycation actives
AMINOGUANIDINE HCL
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
A small molecule that blocks the formation of advanced glycation end products and is used for anti-ageing claims. Pharmaceutical trials were stopped due to side effects, so cosmetic levels and use require caution.
Function
Skin benefits
- Inhibits advanced glycation end product formation in vitro
- Promoted for anti-glycation and anti-ageing skincare claims
- Soluble in water and easy to formulate
Known concerns
- Human clinical development halted due to pro-oxidant effects and side effects
- Documented inhibition of nitric oxide synthase
- Long-term cosmetic safety data are limited
- Potential for irritation and B6 metabolism interference
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.