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AMINOGUANIDINE HCL

CAS 1937-19-5
52

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Aminoguanidine hydrochloride is a small molecule historically studied for its advanced glycation end-product (AGE) inhibiting properties — it can help protect skin from sugar-induced aging damage.

Aminoguanidine HCl (C2H8ClN3) is the hydrochloride salt of aminoguanidine, a compound related to hydrazine and guanidine. Its primary mechanism is inhibiting the formation of advanced glycation end-products (AGEs) by reacting with reactive carbonyl species (dicarbonyls like methylglyoxal). AGEs contribute to skin aging by cross-linking collagen and elastin. However, aminoguanidine has been associated with some safety concerns in internal use studies — it can affect vitamin B6 metabolism and has shown some hematological effects at high systemic doses. For topical cosmetic use at low concentrations, the risk is lower.

Function

SKIN CONDITIONING

Skin benefits

  • Anti-glycation protection
  • Collagen preservation
  • Anti-aging for diabetic or sugar-exposed skin

Known concerns

  • Can affect vitamin B6 metabolism with prolonged systemic exposure
  • Historical concern about hematological effects at high doses
  • Use caution in pregnant/nursing formulations

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.