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AMINOPEPTIDASE

CAS 9031-94-1
76

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A proteolytic enzyme that breaks down proteins into amino acids, used in cosmetic formulations for gentle enzymatic exfoliation.

Aminopeptidase (CAS 9031-94-1) is a proteolytic enzyme that catalyzes the cleavage of amino acids from the N-terminus of proteins. Enzyme-based ingredients in cosmetics may cause skin sensitization in susceptible individuals. The EU Cosmetics Regulation 1223/2009 requires that enzyme preparations be free from viable microorganisms. Proteolytic enzymes are generally well-tolerated on intact skin but may cause irritation on damaged skin. The SCCS has evaluated enzymatic ingredients and recommends appropriate purity standards. The PubChem score of 82 indicates moderate safety concern, primarily related to potential sensitization.

Skin benefits

  • Gentle enzymatic exfoliation
  • May help with skin texture
  • Breaks down dead skin proteins

Known concerns

  • Potential skin sensitizer for susceptible individuals
  • May irritate damaged or compromised skin
  • Requires careful purity assessment

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.