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Amitrole (ISO)

CAS 61-82-5
3

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A herbicide classified as a probable human carcinogen, prohibited in cosmetic products under EU cosmetics regulation.

Amitrole (3-amino-1,2,4-triazole) is an ISO-named herbicide prohibited from use in cosmetic products under EU Cosmetics Regulation (EC) No 1223/2009. It is classified as a Category 2 suspected carcinogen under EU CLP Regulation and has been evaluated by IARC as Group 2A (probably carcinogenic to humans). Amitrole inhibits thyroid hormone synthesis and is listed on EU REACH Authorisation List (Annex XIV), effectively eliminating its use in consumer products. The substance is also toxic to aquatic life with long-lasting effects.

Known concerns

  • Probable human carcinogen (IARC Group 2A)
  • Suspected carcinogen under EU CLP Category 2
  • Prohibited in EU cosmetic products
  • Thyroid hormone synthesis inhibitor
  • Toxic to aquatic life (H400, H410)
  • Listed on EU REACH Authorisation List (Annex XIV)

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.