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Fragrance allergen complex

AMYLCINNAMAL/METHYL ANTHRANILATE SCHIFF BASE

CAS 68527-78-6
38

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Schiff base condensate of amyl cinnamal and methyl anthranilate, two known fragrance allergens. On the skin the bond can hydrolyse to release both parent allergens, contributing to the cumulative fragrance sensitisation load.

Skin benefits

  • Combines floral jasmine and grape-like odour notes
  • Provides long-lasting fragrance character
  • Self-quenching of two reactive fragrance materials

Known concerns

  • Amyl cinnamal is an EU Annex III labelled fragrance allergen
  • Methyl anthranilate has photosensitisation concerns when combined with other UV-active species
  • Schiff base hydrolysis releases both allergenic parents on the skin
  • Combined allergen exposure higher than individual labelling thresholds suggest

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.