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ASCORBYLMETHYLOXO SPERMIDINE HCL

55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A vitamin C and polyamine conjugate with antioxidant properties used in advanced anti-aging skincare, but with minor skin sensitisation potential from the reactive oxo group.

Ascorbylmethyloxo Spermidine HCl is a semi-stable covalent conjugate of L-ascorbic acid, a methyl oxo group, and the polyamine spermidine, designed to deliver antioxidant benefits with enhanced cellular uptake. The methyl-oxo substituent on the ascorbyl moiety introduces mild reactivity concerns; however, the vitamin C backbone is well-established in topical cosmetics. No EU Annex restrictions are documented.

Skin benefits

  • Antioxidant
  • Anti-aging
  • Collagen support

Known concerns

  • Mild sensitisation potential
  • Reactive carbonyl group

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.