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BENZOXIQUINE

CAS 86-75-9
60

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Benzoxiquine (8-hydroxyquinoline benzoate) is a phenolic antimicrobial and UV-absorbing compound used in cosmetics. Related to the preservatives 8-hydroxyquinoline and chlorquinaldol, it is effective against bacteria and fungi but is restricted in the EU due to ozone-layer concerns.

Benzoxiquine (CAS 86-75-9) is the benzoate ester of 8-hydroxyquinoline (8-HQ). It acts as a pro-drug, slowly releasing 8-HQ in cosmetic formulations or on skin. 8-Hydroxyquinoline is a well-known metal chelator and broad-spectrum antimicrobial active against bacteria, fungi, and some viruses. Its mechanism involves metal ion chelation (particularly Fe²⁺ and Mg²⁺) disrupting microbial enzyme systems. Benzoxiquine is listed in EU Annex III under the ozone-depleting substances ban (8-HQ derivatives were historically synthesized using chlorinated chemistry). Skin sensitization and photosensitization are known adverse effects. The estrogenic potential of 8-HQ derivatives has been studied with equivocal results.

Function

ANTIMICROBIAL

Skin benefits

  • Broad-spectrum antimicrobial reduces acne and skin pathogens
  • UV-absorbing properties provide sun protection
  • Metal chelation may help control melanin production

Known concerns

  • EU Annex III restricted for ozone-depleting potential
  • Skin sensitizer — documented allergic contact dermatitis cases
  • Photosensitization possible with UV exposure
  • Possible weak estrogenic activity (equivocal evidence)
  • Metal chelation may disrupt skin enzymes

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.