Biphenyl-4-ylamine (4-Aminobiphenyl) and its salts
Safety score · 0–100
Avoid
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A potent human carcinogen and its salts, banned from cosmetic use in the EU due to demonstrated bladder cancer causation in humans.
4-Aminobiphenyl (biphenyl-4-ylamine) is an aromatic amine that is classified as a Category 1A carcinogen by IARC, with documented causation of bladder cancer in humans. Its salts share the same toxicological concerns as the parent compound. Under EU Regulation 1223/2009 Annex II, this substance and its derivatives are prohibited for use in cosmetic products. The toxicological evidence for this compound represents one of the strongest cases for prohibition, having been identified as a human carcinogen through occupational exposure studies.
Known concerns
- IARC Group 1 confirmed human carcinogen
- EU Annex II banned - no cosmetic use permitted
- Causes bladder cancer in humans
- CMR Category 1A substance
- All salts also prohibited
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.