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BIS-BROMOACETYL 1,6-HEXANEDIAMINE

40

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A reactive bromoacetyl compound used as a crosslinking agent in permanent wave and hair straightening formulations, classified as a potential skin sensitiser due to its alkylating bromoacetyl functionality.

Bis-Bromoacetyl 1,6-Hexanediamine is a bifunctional alkylating agent with two bromoacetyl reactive groups linked by a hexamethylenediamine spacer. It is used in professional hair permanent wave (cold wave) formulations as a protein crosslinker that modifies hair keratin structure. The bromoacetyl group is a potent alkylating agent capable of reacting with nucleophilic amino acid residues in skin proteins, leading to contact sensitisation. EU regulatory restrictions for alkylating agents in cosmetics require careful evaluation. This type of ingredient is typically restricted to professional-use hair care products and excluded from home-use formulations in many jurisdictions.

Known concerns

  • Bromoacetyl reactive compound - potent skin sensitiser
  • Alkylating agent - potential for protein reactivity
  • Used in hair permanent wave compositions
  • EU restriction may apply in certain product types

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.