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BIS-(CARBOXY CERAMIDE NP) POLOXAMER 407

72

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A conjugated ceramide-polymer hybrid combining ceramide NP (a skin barrier lipid) with Poloxamer 407 (a reversible hydrogel polymer), designed to deliver ceramide benefits through an innovative delivery system.

Bis-(Carboxy Ceramide NP) Poloxamer 407 is a sophisticated conjugate where two carboxy-ceramide NP molecules are linked to Poloxamer 407, a tri-block copolymer of polyethylene glycol and polypropylene glycol (PEG/PPG/PEG). The resulting structure is amphiphilic and can form hydrogels or micellar systems that respond to temperature. Ceramide NP is a key lipid component of the stratum corneum, essential for skin barrier function. Poloxamer 407 is a reversible thermosensitive polymer used in pharmaceutical and cosmetic formulations. This conjugate likely aims to improve ceramide delivery and skin deposition.

Skin benefits

  • Delivers ceramide NP to support skin barrier integrity
  • May enhance skin hydration and reduce transepidermal water loss
  • Novel delivery system for skin barrier repair

Known concerns

  • Large molecular weight may limit skin penetration
  • Limited specific safety data for this conjugate in cosmetics
  • Poloxamer 407 generally well-tolerated but rare allergic reactions possible

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.