BIS-(CARBOXY CERAMIDE NP) POLOXAMER 407
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A conjugated ceramide-polymer hybrid combining ceramide NP (a skin barrier lipid) with Poloxamer 407 (a reversible hydrogel polymer), designed to deliver ceramide benefits through an innovative delivery system.
Bis-(Carboxy Ceramide NP) Poloxamer 407 is a sophisticated conjugate where two carboxy-ceramide NP molecules are linked to Poloxamer 407, a tri-block copolymer of polyethylene glycol and polypropylene glycol (PEG/PPG/PEG). The resulting structure is amphiphilic and can form hydrogels or micellar systems that respond to temperature. Ceramide NP is a key lipid component of the stratum corneum, essential for skin barrier function. Poloxamer 407 is a reversible thermosensitive polymer used in pharmaceutical and cosmetic formulations. This conjugate likely aims to improve ceramide delivery and skin deposition.
Skin benefits
- Delivers ceramide NP to support skin barrier integrity
- May enhance skin hydration and reduce transepidermal water loss
- Novel delivery system for skin barrier repair
Known concerns
- Large molecular weight may limit skin penetration
- Limited specific safety data for this conjugate in cosmetics
- Poloxamer 407 generally well-tolerated but rare allergic reactions possible
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.