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Bretylium tosilate (INN)

CAS 61-75-6
22

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Bretylium Tosilate (inn) is a cosmetic ingredient. Exercise caution due to limited available safety data.

Bretylium tosilate is a class III antiarrhythmic agent that affects cardiac repolarisation. Under EU Cosmetics Regulation Annex III, it is restricted to below 0.1% as a constituent of substances or mixtures. Its cardiovascular pharmacological activity makes it inappropriate for general cosmetic use without professional supervision.

Known concerns

  • Restricted in EU cosmetics (Annex III, <0.1%)
  • Class III antiarrhythmic activity
  • Cardiovascular effects
  • Acute toxicity (H302, H312, H332)

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.