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BRUCINE SULFATE

CAS 4845-99-2
12

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A highly toxic strychnine-related alkaloid sulfate from the Strychnos nux-vomica tree used as a pharmaceutical bitter stomachic and stimulant that carries extreme acute toxicity and is absolutely prohibited from cosmetic use.

Brucine Sulfate is the sulfuric acid salt of brucine, a Strychnos alkaloid structurally and mechanistically related to strychnine. Both are convulsant poisons acting on the spinal cord glycine receptors. Brucine has extreme acute oral toxicity (LD50 in rats ~1 mg/kg) and is not permitted in cosmetics under any circumstance. Even trace contamination from this compound would be dangerous.

Known concerns

  • EU Annex II prohibited substance (extremely toxic alkaloid)
  • Extreme acute oral and systemic toxicity
  • Convulsant poison with no cosmetic application whatsoever

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.