Skip to content

Brucine

CAS 357-57-3
5

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Brucine is a cosmetic ingredient. Exercise caution due to limited available safety data.

Brucine is an alkaloid closely related to strychnine, derived from Strychnos nux-vomica. It presents a severe acute toxicity profile with H300 (fatal if swallowed), H330 (fatal if inhaled), and H412 (harmful to aquatic life). The substance has H301 designation as well. EU CosIng lists this substance in Annex II (banned substances list) at concentrations >=0.1%, reflecting the absolute prohibition on highly toxic plant-derived alkaloids in cosmetic products.

Known concerns

  • H300/H301 acute oral toxicity
  • H330 acute inhalation toxicity
  • EU Annex II banned at >=0.1%
  • Strychnine-related alkaloid

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Check your shelf

Find Brucine in your products.

Scan any cosmetic product with LuxSense to see if it contains Brucine and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.