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BUTENYL AMINOLEVULINATE HCL

55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A photosensitizing amino acid derivative — when exposed to certain wavelengths of light it generates reactive oxygen species, making it useful for targeted skin therapies but requiring careful handling.

Butenyl Aminolevulinate HCl (But-ALA) is a modified aminolevulinic acid derivative where the amine group is alkylated with a butenyl chain. Like other ALA derivatives, it serves as a prodrug that is metabolized intracellularly to protoporphyrin IX (PpIX), a photosensitizing porphyrin. Upon light activation at appropriate wavelengths (typically 400-450nm or 630-670nm), PpIX generates cytotoxic singlet oxygen that can destroy targeted cells — the basis of photodynamic therapy. In cosmetic contexts it may be used for photoactivation-based treatments targeting acne or skin rejuvenation. The HCl salt improves aqueous solubility and skin penetration compared to free ALA.

Function

ANTIOXIDANT, SKIN CONDITIONING, SKIN PROTECTING

Skin benefits

  • Enables photodynamic therapy for acne-prone skin
  • May support targeted treatment of hyperpigmentation
  • Controlled ROS generation can stimulate collagen remodeling

Known concerns

  • Photosensitizing agent — increases skin's sensitivity to light dramatically
  • May cause phototoxic reactions if user is exposed to sunlight after application
  • Risk of contact sensitization with repeated use
  • Not suitable for use in leave-on products without professional guidance

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.