Fragrance
BUTYROPHENONE
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
Butyrophenone — an aromatic phenyl ketone used as a minor fragrance material. Thin cosmetic toxicology literature; default-down to orange.
Butyrophenone (phenyl propyl ketone, CAS 495-40-9) is an aromatic ketone used as a fragrance raw material. It is also the structural parent of the butyrophenone-class of antipsychotic drugs (e.g. haloperidol) — the drugs gain their psychoactivity from attached pharmacophores that butyrophenone itself does not carry, so this is structural only. Specific cosmetic dermal-toxicology data are thin; no SCCS opinion or CIR monograph covers the material. Phenyl ketones generally carry mild irritation potential and some photo-reactivity that depends on substitution pattern.
Function
Skin benefits
- Aromatic fragrance component
- Photo-stable ketone building block
- Used at very low levels
Known concerns
- Phenyl ketone — photoreactive in some analogues
- Limited published dermal toxicology specific to cosmetics
- Potential irritation at higher levels
- Structural parent of butyrophenone-class psychoactive drugs (no activity itself)
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related fragrances
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.