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Fragrance

BUTYROPHENONE

CAS 495-40-9
58

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Butyrophenone — an aromatic phenyl ketone used as a minor fragrance material. Thin cosmetic toxicology literature; default-down to orange.

Butyrophenone (phenyl propyl ketone, CAS 495-40-9) is an aromatic ketone used as a fragrance raw material. It is also the structural parent of the butyrophenone-class of antipsychotic drugs (e.g. haloperidol) — the drugs gain their psychoactivity from attached pharmacophores that butyrophenone itself does not carry, so this is structural only. Specific cosmetic dermal-toxicology data are thin; no SCCS opinion or CIR monograph covers the material. Phenyl ketones generally carry mild irritation potential and some photo-reactivity that depends on substitution pattern.

Function

PERFUMING

Skin benefits

  • Aromatic fragrance component
  • Photo-stable ketone building block
  • Used at very low levels

Known concerns

  • Phenyl ketone — photoreactive in some analogues
  • Limited published dermal toxicology specific to cosmetics
  • Potential irritation at higher levels
  • Structural parent of butyrophenone-class psychoactive drugs (no activity itself)

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.