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Calcium bis[3-hydroxy-4-(phenylazo)-2-naphthoate]

CAS 6371-76-2
52

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Calcium Bis[3-hydroxy-4-(phenylazo)-2-naphthoate] is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

This calcium-based azo pigment is listed in EU CosIng with a specific restriction: 'Not to be used in products applied on mucous membranes.' Azo pigments can undergo reductive cleavage under certain conditions to release aromatic amines, some of which are regulated carcinogens. The restriction acknowledges that use on mucous membranes (lips, nasal cavity) may present higher exposure risk. The H302 (harmful if swallowed) classification indicates oral toxicity concern. Cosmetic use in external skin applications and color cosmetics applied to intact skin is permitted, subject to general safety requirements.

Skin benefits

  • Provides red coloration in cosmetic products
  • Used in lipsticks, blushes, and color cosmetics (external use only)
  • Stable pigment with good lightfastness

Known concerns

  • H302 - harmful if swallowed
  • EU restriction - not for mucous membrane application
  • Potential azo bond cleavage releasing regulated amines
  • Limited to external skin use only
  • Pigment safety dependent on dye purity

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.