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Cantharidine

CAS 56-25-7
12

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Cantharidine is a cosmetic ingredient. Exercise caution due to limited available safety data.

Cantharidine is the active blistering agent in cantharides (Spanish fly). It carries H300 (fatal if swallowed), H315 (causes skin irritation), H319 (causes serious eye irritation), and H335 (may cause respiratory irritation). This is one of the most potent natural toxins used historically in folk remedies but now strictly banned. It is in EU Annex II as a prohibited substance for cosmetic use.

Known concerns

  • Highly toxic natural product (H300)
  • Severe skin blistering agent
  • Eye irritation (H319)
  • Respiratory irritation (H335)
  • EU Annex II absolutely prohibited

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.