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Caramiphen (INN) and its salts

CAS 77-22-5
15

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Caramiphen (inn) And Its Salts is a cosmetic ingredient. Exercise caution due to limited available safety data.

Caramiphen is an anticholinergic drug used clinically as an antispasmodic and in the treatment of Parkinson's disease and associated sialorrhea. Its mechanism involves muscarinic receptor antagonism leading to reduced secretions and smooth muscle relaxation. EU Annex III restricts its use in cosmetic products at ≥0.1% concentration. While not acutely toxic, its systemic anticholinergic effects from topical application raise significant safety concerns for cosmetic use.

Known concerns

  • Anticholinergic pharmacological activity
  • Systemic effects from skin absorption
  • Dry mouth, blurred vision, tachycardia risk
  • Restricted to ≤0.1% in EU cosmetics

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.