CARYOPHYLLENE OXIDE
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A sesquiterpene epoxide from clove and black pepper with anti-inflammatory properties, used as a fragrance fixative.
Caryophyllene oxide is a sesquiterpene epoxide derived from beta-caryophyllene (found in clove, black pepper, and cannabis), used as a fragrance ingredient and potential anti-inflammatory agent. The epoxide functional group provides fragrance-fixative properties, while beta-caryophyllene interacts with CB2 receptors in skin. Under EU Regulation 1223/2009, it is classified as a fragrance allergen requiring declaration, and IFRA recommends a maximum use level of 10%.
Skin benefits
- Sesquiterpene epoxide with anti-inflammatory properties
- Used as fragrance fixative and in natural cosmetics
Known concerns
- Potential contact allergen in sensitive individuals
- EU fragrance allergen reporting requirements may apply
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.