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Skin Conditioning

CATHARANTHUS ROSEUS CALLUS CONDITIONED MEDIA

72

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Madagascar periwinkle callus media — plant-stem-cell ingredient. Supplier quality control is critical because the parent plant produces chemotherapy alkaloids.

Catharanthus roseus callus conditioned media is the nutrient-enriched liquid collected after culturing dedifferentiated cells (callus) of Madagascar periwinkle. Plant cell culture avoids wild harvesting and can standardise phytochemical output. The key safety point: Catharanthus roseus is the source of the anti-cancer alkaloids vinblastine and vincristine, which are potent cytotoxic agents. Reputable cosmetic suppliers run callus cultures under conditions that suppress vinca-alkaloid expression and certify below-detection levels; without this guarantee the ingredient carries meaningful concern. No CIR monograph. Use levels are typically very low (0.01-1%).

Function

SKIN CONDITIONING - MISCELLANEOUS

Skin benefits

  • Plant-cell-culture-derived cosmetic active
  • Rich in phytochemicals without harvesting wild plants
  • Positioned for anti-ageing and rejuvenation claims

Known concerns

  • Parent plant (Madagascar periwinkle) produces vinblastine/vincristine — cytotoxic alkaloids — not desired in cosmetics
  • Reputable suppliers confirm no residual vinca alkaloids, but verification is essential
  • Limited independent cosmetic safety data

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.