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Chloroform

CAS 67-66-3
8

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Chloroform is a cosmetic ingredient. Exercise caution due to limited available safety data.

Chloroform (CAS 67-66-3) is a volatile organic solvent that was historically used in cosmetic formulations including nail polish and as a flavoring agent. EU Regulation 1223/2009 Annex II prohibits the use of this substance in cosmetic products. The compound has been associated with hepatotoxicity (liver damage), nephrotoxicity (kidney damage), neurotoxicity (CNS depression), and cardiac toxicity (sensitization leading to arrhythmias). It is classified as a Group 2B probable human carcinogen by IARC. The prohibition ensures consumer safety from both acute and chronic exposure scenarios.

Known concerns

  • EU Annex II banned - probable human carcinogen
  • Hepatotoxicity and nephrotoxicity
  • Neurotoxicity and CNS depression
  • Cardiac sensitization risk
  • No safe cosmetic use concentration

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.