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Chlorzoxazone (INN)

CAS 95-25-0
3

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Chlorzoxazone (inn) is a cosmetic ingredient. Exercise caution due to limited available safety data.

Chlorzoxazone is listed in Annex II of EU Regulation (EC) No 1223/2009. This pharmaceutical muscle relaxant acts on the spinal cord and subcortical brain structures. It has been associated with drug-induced liver injury and rare but serious skin reactions including Stevens-Johnson syndrome. Cosmetic use of this drug substance is prohibited given its systemic pharmacological activity.

Known concerns

  • Prohibited in EU cosmetics (Annex II)
  • Drug substance with CNS/pharmacological activity
  • Hepatotoxicity risk
  • Severe skin reactions including Stevens-Johnson syndrome

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.