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CICLOPIROX OLAMINE

CAS 41621-49-2
55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Ciclopirox Olamine is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Ciclopirox Olamine (CAS 41621-49-2, PubChem CID 38911) is the ethanolamine salt of ciclopirox, a synthetic hydroxypyridone antifungal agent. Listed under EU Annex III/61, it is restricted to specific cosmetic product types (anti-dandruff shampoos) at regulated concentrations (typically ≤1.5%). It works by chelating polyvalent metal cations (Fe³⁺, Al³⁺), inhibiting metal-dependent enzymes in fungal cells. It has broad-spectrum activity against dermatophytes, yeasts (including Malassezia), moulds, and some bacteria. As a pharmaceutical-grade active, it requires careful formulation and concentration control.

Skin benefits

  • Effective antifungal against dandruff-causing Malassezia
  • Broad-spectrum antimicrobial
  • Anti-inflammatory properties
  • Treats seborrheic dermatitis symptoms

Known concerns

  • EU Annex III restricted — limited to specific product types
  • Can cause skin irritation, burning, or stinging
  • Contact dermatitis reported in some users
  • Not for use on broken or inflamed skin
  • Drug-cosmetic regulatory considerations

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.