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Skin Conditioning

CUCURBITACIN B

CAS 6199-67-3 Updated
15

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A potent cytotoxic triterpenoid from gourd plants (the bitterness in spoiled cucumbers). Linked to acute poisoning at oral doses. Not appropriate as a routine cosmetic active given its potency.

Skin benefits

  • Studied for anti-inflammatory and anti-cancer pharmacology

Known concerns

  • Highly cytotoxic plant toxin
  • Cucurbitaceae poisoning cases reported
  • No CIR or SCCS safety review
  • Inappropriate as a routine cosmetic ingredient

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.